克罗米酚对男性低促性腺素性功能减退症必要

纽约（另据健康版）1月四日报道：据发表在12月再版的《生育与不育》杂志的一项调查结果指出克罗米酮对部分很低促特质腺素在特质功能急剧下降的年长者高血压有利。来自普雷斯顿阿拉巴马大学的该调查结果的第一写作者Scott J. Whitten芝加哥大学在给与路透中央社采访时说：“原发特质或获得特质HH高血压在给与侵害特质更大和更廉价的治疗（例如注射促特质腺激素在类）前顺利进行4个月的克罗米酮试验特质治疗是有利的。”Whitten芝加哥大学和同事研究了克罗米酮对10名HH年长者高血压（HH是导致年长者不育的少见原因）是否有效。调查结果所称克罗米酮治疗1年后，4名康拉德(氏)综合征高血压中只有一名高血压的乳腺浓度增加而全垂体功能急剧下降症高血压的乳腺忽视症状以外没有得到改善。相反，该调查结果指出3名成年得病的原发特质HH年长者高血压经过3个月克罗米酮的治疗乳腺浓度有了明显增加。目前为止该组高血压已是两名恢复了哺育。Whitten芝加哥大学说：“除非对克罗米酮治疗没有重排，我们不会因为副作用暂时对高血压应用于该药物。”最后写作者阐释说：“因为情况下可用，对HH高血压促特质腺激素在类药物和克罗米酮的随机研究无法顺利进行，然而利用多系列的严格选取标准对高血压顺利进行基准也许帮助必要特质验证克罗米酮恢复年长者很低哺育的有效特质。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

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编辑： 张靖